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Federico Mazzola: Silver catalyzed Fluorouracil degradation; a promising new role for graphene

posted 17 Jun 2015, 06:11 by info admin

Norwegian University of Science and Technology (NTNU), N-7491 Trondheim, Norway


Chemotherapy is a major part of many people’s lives. In the treatment of cancer, the drug is delivered into the body of the patients via catheters. Such catheters are prone to degradation and create unpleasant side effects, causing severe complications to patients. In order to prevent or reduce such a degradation, catheters and the associated delivery apparatus are increasingly coated with Ag-alloys. These coatings are particularly common because of their low reactivity and antimicrobial properties. Surprisingly, the surface reaction between chemotherapy drugs and catheter materials/coatings is generally unexplored. We recently demonstrated that an incredibly strong reaction can occur, with a subsequent release of HF. We further investigated other inert coating-materials, such as graphene, finding no sign of chemical reaction. The research suggests that placing graphene on the internal surfaces of catheters commonly used to deliver chemotherapy drugs into a patients body will improve the efficacy of treatments, and reduce the potential of the catheters failing. We believe that graphene coatings could constitute a potential candidate for the next generation of drugs delivery systems.


Federico Mazzola is a PhD student at the Norwegian University of Science and technology (NTNU) under the supervision of Prof. Justin Wells. He has experiences in various synchrotron-based techniques such as Angle resolved photoemission spectroscopy (ARPES), spin-ARPES, resonant photoemission spectroscopy and X-ray photoemission spectroscopy (XPS). He is currently working on the electronic properties of graphene, shallow delta layers in semiconductors, transition metal dichalcogenides and topological insulators under the supervision of Prof. Justin Wells. Previous to this, he got his M. Physics in Condensed Matter Physics at University of Rome, La Sapienza with a thesis project carried out in Denmark at Aarhus University under the supervision of Prof. Philip Hofmann on ARPES-based studies on graphene at the synchrotron facility ASTRID (now ASTRID2) (SGM-3 beamline, Aarhus, DK).