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Rajendra Kurapati: Dispersibility and functionalization dependent biodeg-radation of graphene oxide

posted 17 Jun 2015, 06:48 by info admin

CNRS, Institut de Biologie Moléculaire et Cellulaire, Laboratoire d’Immunopathologie et Chimie Thérapeutique, Strasbourg 67000

Understanding human health risk associated with the use of the rapidly emerging graphene-based nanomaterials represents a great challenge because of the diversity of applications and the wide range of possible ways of exposure to this type of materials. Herein, we report the biodegradation of graphene oxide (GO) using enzymatic catalysis by peroxidases like myeloperoxidase (hMPO), horseradish peroxidase (HRP) in the presence of a low concentration of hydrogen peroxide. First, we demonstrated the dispersibility dependent biodegradation of GO by hMPO using different GO samples containing different degree of oxidation on their graphenic lattice, where hMPO failed to degrade the most aggregated GO, but succeeded to completely metabolize highly dispersed GO samples. Further to enhance the biodegradability, we covalently functionalized GO with specific molecules like coumarin catechol derivatives. Both types of molecules are known as the good reducing substrates and strong redox mediators to enhance the catalytic activity of HRP. Our results revealed that biodegradation of functionalized GO was faster and more efficient over unmodified GO. Over all, our work may give an adequate solution for the serious concerns raised for developing graphene-based nanomaterials.

(Ref: R. Kurapati, A. Bianco et al. Dispersibility-Dependent Biodegradation of Graphene Oxide by Myeloperoxidase. Small, 2015 10.1002/smll.201500038).

 

Rajendra Kurapati is currently a Postdoctoral Fellow at CNRS, Institut de Biologie Moléculaire et Cellulaire, Laboratoire d’Immunopathologie et Chimie Thérapeutique in Strasbourg. He is mainly interested in biomedical applications as well as nano-toxicology of carbon-based materials including newly emerging 2-dimensional materials. He received his M.S. degree in Chemistry from University of Hyderabad (20008) and a Ph.D. in Material Science and Engineering (2014) from Indian Institute of Science where he investigated the drug delivery and antimicrobial applications of self-assembled graphene oxide/polymer materials. After finishing his Ph.D., he spent 8 months as a postdoctoral researcher in the Laboratory of Biomaterials at the Indian Institute of Science studying graphene oxide/nanoparticles composites for bioimaging applications before joining the group at IBMC, Strasbourg in April, 2014. His awards include a Ph.D. fellowship from the Council of Scientific and Industrial Research (CSIR), India (2008-2014) and Lectureship in

Chemistry by CSIR/UGC, India in 2007.

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